Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

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Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

Vascular development requires an orderly exchange of signals between growing vessels and their supporting tissues, but little is known of the intracellular signaling pathways underlying this communication. We find that mice with disruptions of both NFATc4 and the related NFATc3 genes die around E11 with generalized defects in vessel assembly as well as excessive and disorganized growth of vesse...

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ژورنال

عنوان ژورنال: Cell

سال: 2001

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(01)00396-8